Uryu Kamihate has had a rough start to life, but plans to forget it all by achieving his dream-matriculating into medical school. But when he arrives at his new foster home, a working shrine, his dream of a quiet place to study goes up in smoke. Not only will he be living with the three beautiful, lively Amagami sisters-but he learns that he must marry one of them and take over the shrine!
In the wake of his second round of marriage interviews, Uryu has fallen even deeper in love with the three sisters. As each sister struggles with an issue in her life—Asahi with track club, Yuna with the shrine, Yae with her art—something unexpected happens. Yae vanishes, leaving only a note behind! Unable to give up an important member of their family, Yuna, Asahi, and Uryu resolve to take her back from her birth family, the Ichijoji Family, at any cost!