Issue 1
The Adventure Begins Part 1
While attending college, 19-year old twins, Marty and Eli Powers, are revealed to have superpowers that were granted to them when they were younger. They also discover that there are people who want to take away and synthesize those powers for their own use.
Issue 2
The Adventure Begins Part 2
Marty and Eli learn from Mocha how they got their powers and then she shows them how to use them to free their Uncle Brian, who has been taken hostage by Dr. Atlas.
Issue 3
With Great Powers... Part 1
After defeating Dr. Atlas, Marty and Eli must face Dr. Brubaker and his teaching assistant Dr. Reynolds. Followers of Dr. Atlas', they are determined to carry on their work and defeat the Powers twins in the name of science.
Issue 4
With Great Powers... Part 2
Eli, along with Kirby, Steve and Don, gets caught in a trap set by Dr. Brubaker. Marty and Mocha must come to their rescue.
Issue 5
With Great Powers... Part 3
After freeing themselves from Dr. Brubaker, Marty and Eli discover new foes and a new power.
Issue 6
Kirby Good and Evil Part 1
With Marty and Eli getting all the attention, Kirby feels like he's been left behind. That is until the mysterious Dr. Jordan offers to make him exceptional, too.
Issue 7
Kirby Good and Evil Part 2
With the help of Dr. Jordan, Kirby develops similar powers to Marty and Eli, but is unaware of Jordan's ulterior motives.
Issue 8
Mathemagical Part 1
The boys confront a new villain, Dr. Patricia Theorem, who has powers they have never encountered before. Dr. Atlas, with Instructor Miller at his side, makes his return!
Issue 9
Mathemagical Part 2
In the thrilling conclusion of the Mathemagical story arc, Marty and Eli confront Professor Theorem; and it seems a certain mad scientist hasn't faded away.
Issue 10
What's in a Name? Part 1
Things get dangerous for Marty and Eli when they combat a new villain, the Convincer. Meanwhile, after an interview, the school newspaper's editor, Quincy Victoria Davidson develops a love interest in Marty.
Issue 11
What's in a Name? Part 2
Marty and Eli start to drift as their new relationships take priority. However, they are not out of harm's way as another attempt is made on their lives.
Issue 12
What's in a Name? Part 3
Marty and Eli have each other's back but continue to be drawn apart by the events and people in their lives. Could this be the end of Powers Squared?
Issue 13
The Imposter Part 1
Just when relationships appear to be pulling Marty and Eli apart, someone on campus tries ruining Marty's reputation by impersonating him. Who could it be?
Issue 14
The Imposter, Part 2
With the help of Mocha and former adversary Professor Theorem, Eli tries to rescue Marty before he becomes a pawn in Dr. Atlas' plans.
Issue 15
How They Met
The day that Mocha met Marty and Eli Powers would change all three of their lives.
Issue 16
Mocha and Raven, Part 1
Billy O'Shea returns to the story with a yokai named Raven and it's not good news for Marty and Eli.
Issue 17
Mocha and Raven, Part 2
Billy O'Shea meets Raven and their relationship blossoms as they are both targets of Dr. Atlas.
Issue 18
Mocha and Raven, Part 3
With the help of Billy and Raven, Marty, Eli and Mocha manage to turn the tables on Dr. Atlas and his evil plan.
Issue 19
Kamaitachi
Riding on the wind, three Kamaitachi descend on San Romero Community College looking for Marty and Eli.
Issue 20
Misson: Istanistan, Part 1
The U.S. Army enlists Marty and Eli Powers to work on a classified secret mission to stop a rogue nation, Istanistan, from completing work on a WMD. The mission seems simple, one will teleport in and do the work and the other will use telepathy to guide them. It's a dangerous mission, but what could go wrong?
Issue 21
Mission: Istanistan, Part 2
When Marty loses contact with Eli, he knows that something's gone wrong with the mission. Unlike the Army, Marty isn't willing to write off his brother's life and, against orders, goes to find him. But will he reach him in time as the clock is ticking?
Issue 22
Family Affair, Part 1
After all they’ve been through, there is very little that scares Marty and Eli. That is until Peter and Peggy Powers, their estranged parents, come to town. And while Marty and Eli have their own secrets, there’s more to mom and dad than the boys are supposed to know.
Issue 23
Family Affair, Part 2
Marty and Eli learn the truth about their parents, but not before Peggy and Peter Powers put Jenny in danger. With Mocha's help, the boys stage a rescue and hope they can survive their parents' visit.
Issue 24
Gashadokuro
Marty and Eli have been through a lot together, but need to be apart during school hours. Unfortunately, not even Eli's art class is safe from an enemy attack.
Issue 25
Yuki-Onna
During Eli's battle with a Gashadokuro, Marty shows a new student, Affogato, around school. Unfortunately, she turns out to be a Yuki-Onna, a yokai known for freezing their victims. Can Marty survive her cryogenic touch?