The son of a famous pianist, music student Shinichi Chiaki dreams of studying abroad and becoming a conductor like his mentor. Unfortunately, his fear of flying grounds his lofty plans! As he watches other classmates achieve what he has always wanted, Shinichi wonders if he should quit music altogether. Then one day he meets fellow student Megumi Noda, also known as Nodame. This oddball girl cannot cook, clean, or even read a music score, but she can play the piano in incomparable Cantabile style. And she teaches Chiaki something that he has forgotten: to enjoy his music, no matter where he is.
It’s showtime for Shinichi’s new Rising Star Orchestra. Renowned critics and famous musicians have gathered to see the debut performance. Meanwhile, Nodame is playing hypnotist on Shinichi, trying to cure him of his fear of flying. After all, she wants her true love to be able to perform abroad. But will the concert take Shinichi’s career to the next level? And if Nodame succeeds in freeing Shinichi of his panic attacks, will she be left behind? It’s anybody’s guess in this symphony of conflicted decisions, crushes, and pianos!