The son of a famous pianist, music student Shinichi Chiaki dreams of studying abroad and becoming a conductor like his mentor. Unfortunately, his fear of flying grounds his lofty plans! As he watches other classmates achieve what he has always wanted, Shinichi wonders if he should quit music altogether. Then one day he meets fellow student Megumi Noda, also known as Nodame. This oddball girl cannot cook, clean, or even read a music score, but she can play the piano in incomparable Cantabile style. And she teaches Chiaki something that he has forgotten: to enjoy his music, no matter where he is.
Paris is full of young lovers and aspiring artists. Nodame and Chiaki happen to be both, but soon they may have to make a choice! It seems that the more time Nodame spends with Chiaki, the more her piano playing hits a sour note. Will Nodame have to choose between music and love?