When a meteor crashes in the middle of campus, the students at Pullman University didn't realize that they were being invaded. These space creatures are able to inhabit and take over the human body. So, what happens when a group of cheerleaders are caught in the middle? They become these flesh-eating cannibals, of course.
After the events at Pullman University in Flesh-Eating Cheerleaders from Outer Space, they thought they had the space worms all bottled up. But two managed to escape, and made their way down to Daytona Beach for Spring Break! They plan to feed as much as they can. But something is wrong, one of the girls is regaining control of her senses. What are the space worms to do if she becomes fully aware of what she's doing?