In a world where mutants and superheroes are a rarity, a dangerous mutagenic street drug called Rush runs rampant in the streets of London, turning people into mutant monsters. In this pandemonium, three strange heroes will rise to the occasion, and must fight to keep their crime-fighting and normal lives separate... but that can be difficult when the three of you are roommates.
A few days after their encounter with a monster in the sewers, Roarke, Wilhelm and Crowe discovered that they had drawn attention from the International Department of Superhuman Affairs, and are commissioned to assist the London Branch of IDOSA with a new and pressing issue. Roarke, meanwhile struggles with both his own power suppressant backlash, and personal issues involving the IDOSA director.