Angelo Mortalli has become the ultimate killing machine. His memories were erased and his blood was infused with microscopic computers called nanites. These nanites allow him to heal wounds quickly, dominate electronic devices, and fully control every aspect of his body to maximize his physical capabilities. A modern-day Frankenstein, he wages a one man war-- taking out the mob, the police and his covert government creators-- in his struggle to find out who he was and what he has become.
While on assignment in Hong Kong, Neville Alcott's daughter is taken hostage by a crime cartel run by a former MI-6 agent and the soul-eater known as Sosa. Now its down to Bloodshot to run a one-man rescue mission into hostile terrtory and get her out alive!