Angelo Mortalli has become the ultimate killing machine. His memories were erased and his blood was infused with microscopic computers called nanites. These nanites allow him to heal wounds quickly, dominate electronic devices, and fully control every aspect of his body to maximize his physical capabilities. A modern-day Frankenstein, he wages a one man war-- taking out the mob, the police and his covert government creators-- in his struggle to find out who he was and what he has become.
Bloodshot visits the neighborhood he grew up in and is mistaken for infamous mob enforcer Bruno Mortalli, his own half-remembered father! When he learns that the F.B.I. is hot on his father's trail, Bloodshot joins in the hunt. When father and son reunite it won't be peaceful, and little remain the same after this final confrontation of Bloodshot and his past.