Angelo Mortalli has become the ultimate killing machine. His memories were erased and his blood was infused with microscopic computers called nanites. These nanites allow him to heal wounds quickly, dominate electronic devices, and fully control every aspect of his body to maximize his physical capabilities. A modern-day Frankenstein, he wages a one man war-- taking out the mob, the police and his covert government creators-- in his struggle to find out who he was and what he has become.
With his memories returned, Bloodshot confronts Angelo Mortalli's crime-ridden past. Bloodshot then reunites with an old, wounded friend whom he has to protect from the deadly pair of twin assassins known as the Stilettos.