Angelo Mortalli has become the ultimate killing machine. His memories were erased and his blood was infused with microscopic computers called nanites. These nanites allow him to heal wounds quickly, dominate electronic devices, and fully control every aspect of his body to maximize his physical capabilities. A modern-day Frankenstein, he wages a one man war-- taking out the mob, the police and his covert government creators-- in his struggle to find out who he was and what he has become.
Jillian Alcott is wanted for murder by the U.S. government. But if Bloodshot can't crack the secrets of the Project Hope and Glory parahuman genetics program he discovered deep inside the original Project Rising Spirit records, and keep the nanites transfused into her blood from burning her whole body out, she won't live long enough to be taken into custody.