Angelo Mortalli has become the ultimate killing machine. His memories were erased and his blood was infused with microscopic computers called nanites. These nanites allow him to heal wounds quickly, dominate electronic devices, and fully control every aspect of his body to maximize his physical capabilities. A modern-day Frankenstein, he wages a one man war-- taking out the mob, the police and his covert government creators-- in his struggle to find out who he was and what he has become.
Bloodshot and MI-6 are chasing the Colombian drug cartels all over London and coming up empty. Bloodshot's convinced they're being setup, but that won't be enough to protect Neville Alcott when the British government calls for his resignation. Will Bloodshot figure who's working against them in time, or will he too fall victim to the ambitions of the new director of MI-6?